Flush DNS of malicious domain/IP:

C:\\> ipconfig /flushdns

Flush NetBios cache of host/IP:

C:\\> nbtstat -R

Add new malicious domain to hosts file, and route to localhost:

C:\\> echo 127.0.0.1 <MALICIOUS DOMAIN> >>
C:\\Windows\\System32\\drivers\\etc\\hosts

Check if hosts file is working, by sending ping to 127.0.0.1:

C:\\> ping <MALICIOUS DOMAIN> -n 1